Professor Stephen Gordon, MA MD FRCP DTM&H

Appointment: Chair in Respiratory Medicine Areas of interest: Susceptibility to lung infection, pneumococcal disease and inhaled vaccines

Background: Professor Gordon joined the Liverpool School in 2005, with a remit to establish laboratory and clinical research on susceptibility to pulmonary infections in the School. Prior to his appointment, he had completed two Wellcome Trust Research Fellowships in Blantyre, Malawi and a Clinical Lectureship in the University of Sheffield.

Stephen's research in Sheffield and Malawi focused on susceptibility to respiratory infection and in particular, on the effect of HIV infection on susceptibility to pneumococcal disease. The work demonstrated that pulmonary mucosal defence is regulated differently than systemic defence against infection, and can be perturbed by environmental exposures including indoor air pollution.

The Respiratory Infection laboratory now focuses on mechanisms for antigen presentation to the mucosal surface leading to effective mucosal defence against bacterial infections. We also study the effect of biomass fuel smoke on defence against infection.

Recent work includes a study of inhaled pneumococcal polysaccharide vaccine, assessment of the pulmonary response to pneumococcal conjugate vaccine and the current study of experimental pneumococcal carriage as a pulmonary antigen challenge. Work on biomass fuel smoke indicates that acute and chronic exposures result in very different immune responses, probably leading to altered defence against infection and COPD by different mechanisms.

Stephen holds an Honorary Consultant Contract in General Medicine in the Royal Liverpool University Hospital and University Hospital Aintree. He combines Respiratory and General Medicine with research and teaching in the School.

Teaching: Course Founder: Pan African Thoracic Society Methods in Epidemiologic, Clinical, and Operations Research (PATS-MECOR) course. DTM&H tutor, PhD and MSc supervisor in Human Immunity, Microbiology and Tropical Medicine. Research

Main interests include pulmonary factors contributing to suscepti